منابع مشابه
NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.
Members of the NLR family can assemble inflammasome complexes with the adaptor protein ASC and caspase-1 that result in the activation of caspase-1 and the release of IL-1β and IL-18. Although the NLRC4 inflammasome is known to have a protective role in tumorigenesis, there is an increased appreciation for the inflammasome-independent actions of NLRC4. Here, we utilized a syngeneic subcutaneous...
متن کاملMelanoma biology and progression.
A group of 25 investigators met on November 6–8, 2000 in Bethesda, MD for the purpose of accelerating progress in understanding the biological events in melanoma as they relate to etiology, immune response, and progression. The format of the meeting was the presentation of brief reports that focused on concepts rather than specifics, with extensive discussion periods to identify the issues and ...
متن کاملDextran sulfate suppresses cell adhesion and cell cycle progression of melanoma cells.
We have reported that dextran sulfate is a possible candidate for an antimetastatic drug because it inhibits cell adhesion. It has been demonstrated that dextran sulfate can detach cancer cells adhering to the bottom of plastic flasks, and that the detached cells do not readhere or proliferate. In this study, we investigated the effects of dextran sulfate on cancer cells, focusing on cell cycle...
متن کامل[Endocrine factors influencing melanoma progression].
According to recent findings that beside cancers traditionally considered as hormone-dependent, several other tumor types show different behavior in the two sexes, indicating the possible role of endocrine factors in the course of these diseases. The possibility that endocrine factors may influence the clinical course of human malignant melanoma is suggested by the higher survival rate in preme...
متن کاملPTRF suppresses the progression of colorectal cancers
As a key component of caveolae structure on the plasma membrane, accumulated evidence has suggested that Polymerase I and Transcript Release Factor (PTRF) plays a pivotal role in suppressing the progression of human malignances. However, the function of PTRF in the development of colorectal cancers is still unclear. Here we report that the expression of PTRF is significantly reduced in tumor ti...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2015
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3936